Why the study?
Does a brief period of hypoxic perfusion prior to ischemia reduce reperfusion arrhythmias and preserve sarcoplasmic reticulum function in rat hearts?
Does a brief period of hypoxic perfusion prior to ischemia reduce reperfusion arrhythmias and preserve sarcoplasmic reticulum function in rat hearts?
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May attenuate reperfusion arrhythmias via SR preservation in rat hearts; leaves open translation to clinical ischemia-reperfusion injury.
We previously reported that a brief period of hypoxic perfusion (BHP) prior to ischemia in rat hearts improved functional recovery upon reperfusion with reduced CaZf overload. The present study was designed to determine whether the effect of BHR would be associated with a reduction in reperfusion arrhythmias and a preservation of function of the sarcoplasmic reticulum (SRI. Methods: Hearts were subjected to 40 min of global &hernia and 30 min of reperfusion after a 20 min period of oxygenated perfusion (oxygenated group: OG), or a 10 min period of oxygenation and 10 min of hypoxic perfusion (hypoxic group: HG). We evaluated the release of Ca'+ by SR blocked by ryanodine, the recovery of left ventricular function, and the reperfusion induced ventricular tachycardia/fibrillation (VT/VF).
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Tani et al. (1996) studied this question.
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