Key result
End-stage renal disease independently reduced transverse radial strain rate (β -0.833) and circumferential strain rate (β -0.976) of the common carotid artery compared to normal renal function.
Why the study?
Does speckle-tracking carotid strain ultrasonography detect impaired multidirectional movements of the common carotid artery in patients with end-stage renal disease compared to normal controls?
Cross-Sectional (n=121)
No
Does speckle-tracking carotid strain ultrasonography detect impaired multidirectional movements of the common carotid artery in patients with end-stage renal disease compared to normal controls?
Mean Difference: -0.833 (95% CI -1.39–-0.275)
Absolute Event Rate: 0.72% vs 0.97%
p-value: p=0.004
Multidirectional carotid strain analysis using speckle-tracking ultrasonography can independently detect arterial stiffening in ESRD patients, providing more value than conventional aortic stiffness indices.
Speckle-tracking carotid strain may detect arterial stiffening in ESRD; leaves open incremental value over conventional indices in prospective studies.
BACKGROUND: Arterial stiffening is a major contributing factor in the development of cardiovascular disease in patients with end-stage renal disease (ESRD). However, there is no gold standard for evaluating arterial stiffness. This study aimed to evaluate the newly developed speckle-tracking carotid strain imaging method in assessing arterial stiffness in patients with ESRD. METHODS: In total, 85 patients with normal renal function (controls) and 36 with ESRD were enrolled in this single-center study. Carotid B-mode ultrasonography was performed for all patients. Arterial stiffness indices and strain parameters of the common carotid arteries were analyzed. Values were compared between the groups, and multivariate linear regression analysis was performed to assess the impact of ESRD on carotid strain. RESULTS: There were no differences in the intima-media thickness, β stiffness index, and arterial compliance, but arterial distensibility was lower, and the elastic modulus and pulse wave velocity β (PWV) were higher among patients with ESRD (all p < 0.05), whether assessed in the longitudinal or transverse plane. Both longitudinal and transverse strain rates were reduced in patients with ESRD (all p < 0.05). In multivariate analyses, ESRD independently reduced both transverse radial strain and strain rate (all p < 0.05), and the transverse circumferential strain and strain rate (p < 0.05). However, all conventional aortic stiffness indices and longitudinal strain parameters were not associated with ESRD. CONCLUSIONS: Speckle-tracking carotid strain ultrasonography was successfully performed in both normal subjects and patients with ESRD. Multidirectional carotid strain analyses may provide more value than conventional aortic stiffness indices for risk stratification in patients with ESRD.
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Lee et al. (2018) conducted a cross-sectional in End-stage renal disease (n=121). End-stage renal disease vs. Normal renal function was evaluated on Transverse radial strain rate (β -0.833, 95% CI -1.390 to -0.275, p=0.004). End-stage renal disease independently reduced transverse radial strain rate (β -0.833) and circumferential strain rate (β -0.976) of the common carotid artery compared to normal renal function.
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