Key result
Intracellular Ca2+-overload plays a critical role in the pathogenesis of cardiac dysfunction, cellular damage, and metabolic defects in various cardiovascular diseases.
Design
Review
Authors
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May guide Ca2+-targeted therapies; leaves open clinical efficacy in cardiovascular diseases.
This review highlights that intracellular Ca2+ overload drives cardiac dysfunction through mitochondrial energy depletion and subcellular remodeling, suggesting cardiac genes and calcium handling as potential therapeutic targets.
Nusier et al. (2020) conducted a review in Heart Disease. Intracellular Ca2+-overload was evaluated. Intracellular Ca2+-overload plays a critical role in the pathogenesis of cardiac dysfunction, cellular damage, and metabolic defects in various cardiovascular diseases.
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