November 21, 2000CirculationOpen Access

Lack of Direct Role for Calcium in Ischemic Diastolic Dysfunction in Isolated Hearts

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Population

Isolated, perfused isovolumic (balloon in left ventricle) rat and rabbit hearts

Comparison

Low-flow ischemia and experimentally altered… vs Baseline state or low-flow ischemia without…

Design

Preclinical

Authors

FEFranz R. EberliInterventional Cardiology HSHinrik StrömerPraxis für Humangenetik MFMargaret FerrellMemorial Hospital of South Bend

Discussion

Member takes

Implication

Challenges calcium-activated tension as mediator of ischemic diastolic dysfunction in this model; leaves open human relevance.

Structured PICO

Population

Isolated, perfused isovolumic (balloon in left ventricle) rat and rabbit hearts

Intervention

Low-flow ischemia and experimentally altered calcium availability (increased extracellular calcium from 1.5 to 16 mmol/L, intracoronary high-molar calcium chloride infusion, or EGTA infusion)

Comparator

Baseline state or low-flow ischemia without altered calcium

Outcome

Left ventricular diastolic pressure and intracellular calcium levels (measured by aequorin)surrogate

Ischemic diastolic dysfunction does not appear to be directly mediated by calcium-activated tension, as experimentally increasing calcium during ischemia did not worsen left ventricular diastolic pressure.

Cite This Study

Eberli et al. (2000) studied this question.

synapsesocial.com/papers/6a858fe7d1e5e0588dd4e533 https://doi.org/10.1161/01.cir.102.21.2643

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