May 1, 1996Circulation Research
Adrenergic Modulation of Ultrarapid Delayed Rectifier K+Current in Human Atrial Myocytes
Why the study?
Does adrenergic stimulation modulate the ultrarapid delayed rectifier K+ current (IKur) in human atrial myocytes?
Population
human atrial myocytes
Comparison
Adrenergic stimulation vs Control conditions and specific kinase/receptor…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May modulate atrial repolarization; hypothesis-generating for arrhythmia mechanisms, requires in vivo confirmation.
Structured PICO
Does adrenergic stimulation modulate the ultrarapid delayed rectifier K+ current (IKur) in human atrial myocytes?
P
Population
human atrial myocytes
I
Intervention
Adrenergic stimulation (isoproterenol for beta-adrenergic, phenylephrine for alpha-adrenergic)
C
Comparator
Control conditions and specific kinase/receptor inhibitors (propranolol, PKI(6-22)amide, H-7, prazosin, bisindolylmaleimide)
O
Outcome
Ultrarapid delayed rectifier K+ current (IKur)surrogate
Beta-adrenergic stimulation enhances and alpha-adrenergic stimulation inhibits IKur in human atrial myocytes, revealing a potential mechanism for atrial repolarization and arrhythmias.
Cite This Study
Wang et al. (1996) studied this question.