December 24, 2003Journal of Biological ChemistryOpen Access

Molecular Basis for Kv1.5 Channel Block

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Population

Xenopus oocytes expressing wild-type and mutant Kv1.5 potassium channels

Design

Preclinical

Authors

NDNiels DecherPhilipps University of Marburg BPBernard PirardNovartis (Switzerland)FBFlorian BundisSanofi (Germany)

Discussion

Member takes

Implication

Maps Kv1.5 binding residues for S0100176; leaves open whether this advances selective atrial antiarrhythmics in humans.

Structured PICO

Population

Xenopus oocytes expressing wild-type and mutant Kv1.5 potassium channels

Intervention

S0100176 (N-benzyl-N-pyridin-3-yl-methyl-2-(toluene-4-sulfonylamino)-benzamide hydrochloride)

Outcome

IC50 of S0100176 and identification of key binding residuessurrogate

Identification of key binding residues for the novel Kv1.5 inhibitor S0100176 provides molecular insights for developing targeted therapies for atrial arrhythmias.

Cite This Study

Decher et al. (2003) studied this question.

synapsesocial.com/papers/6a85910f37bcb8373dadabc1 https://doi.org/10.1074/jbc.m307411200

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Molecular Basis for Kv1.5 Channel Block

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Molecular Basis for Kv1.5 Channel Block

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider