Population
Hemodynamically compensated spontaneous hypertensive rats, Wistar rats with healed myocardial infarction…
Comparison
In vitro assessment of left ventricular… vs Age-matched Wistar control rats (CON).
Design
Preclinical
Authors
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Animal data suggest differential SR calcium handling in hypertrophy vs post-MI; leaves open translation to human HF.
The sarcoplasmic reticulum plays an increased role as a source of activator calcium in the hypertrophied muscle of spontaneous hypertensive rats, an adaptation that helps maintain normal cardiac function but does not occur after myocardial infarction.
Mill et al. (1998) studied this question.
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