Key result
Huoxin Pill (50 mg/kg/day) significantly enhanced myocardial function and attenuated cardiac apoptosis and fibrosis in a mouse model of myocardial infarction.
Why the study?
Huoxin Pill is widely used for coronary heart disease and angina pectoris, but its underlying protective mechanism on cardiac apoptosis and fibrosis had not been evaluated.
Does Huoxin Pill improve cardiac function and attenuate apoptosis and fibrosis in a mouse model of myocardial infarction?
Does Huoxin Pill improve cardiac function and attenuate apoptosis and fibrosis in a mouse model of myocardial infarction?
Huoxin Pill improves cardiac function and attenuates adverse remodeling in a mouse model of myocardial infarction by suppressing p53-mediated apoptosis and TGF-β1/Smad2/3-mediated fibrosis.
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Hypothesis-generating for Huoxin Pill in murine MI remodeling; leaves open human translation pending clinical trials.
Shen et al. (2020) studied Myocardial infarction (n=18). Huoxin Pill (HXP) vs. Saline was evaluated on Myocardial function, heart weight index (HWI), and pathological changes. Huoxin Pill (50 mg/kg/day) significantly enhanced myocardial function and attenuated cardiac apoptosis and fibrosis in a mouse model of myocardial infarction.
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