Key result
Allogeneic mating and resulting fetal microchimerism was associated with lower anti-MyHC-α614–629 antibody production and reduced inflammatory infiltrate in experimental autoimmune myocarditis.
Why the study?
To investigate the presence and influence of fetal microchimerism in the cardiac tissue of mated female mice submitted to experimental autoimmune myocarditis.
Does fetal microchimerism mitigate the inflammatory response in experimental autoimmune myocarditis in mice?
Does fetal microchimerism mitigate the inflammatory response in experimental autoimmune myocarditis in mice?
Allogeneic cells of fetal origin may mitigate the inflammatory response in experimental autoimmune myocarditis.
Answers are grounded in this paper and cite their sources.
May attenuate murine autoimmune myocarditis inflammation; hypothesis-generating for human relevance.
Objective: We investigated the presence and influence of fetal microchimerism in the cardiac tissue of mated female mice submitted to experimental autoimmune myocarditis. Materials and methods: Nulliparous BALB/c females and BALB/c females mated with either BALB/c males (syngeneic mating) or C57BL/6 males (allogeneic mating) were immunized with cardiac myosin peptide MyHC-α614-629 or kept as non-immunized controls. Immunization occurred 6-8 weeks after delivery and mice were assessed after 21 days. Results: Immunized mice of allogeneic mating had a lower production of anti-MyHC-α614–629 antibodies compared to immunized nulliparous mice. Immunized nulliparous females had an intense mononuclear inflammatory infiltrate in cardiac tissue, associated with fibroplasia, while mated females had a lower inflammatory reaction. An increase in the frequency of microchimeric fetal cells was observed in mice submitted to allogeneic mating following immunization. Conclusion: Allogeneic cells of fetal origin could contribute to mitigating the inflammatory response in experimental myocarditis.
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Ribeiro et al. (2021) studied Experimental autoimmune myocarditis. Allogeneic mating (fetal microchimerism) vs. Nulliparous mice and syngeneic mated mice was evaluated on Anti-MyHC-α614–629 antibodies and inflammatory infiltrate. Allogeneic mating and resulting fetal microchimerism was associated with lower anti-MyHC-α614–629 antibody production and reduced inflammatory infiltrate in experimental autoimmune myocarditis.
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