Population
Inbred 3-week-old A/J mice inoculated intraperitoneally with coxsackievirus B3 (Nancy strain; 2 x 10…
Comparison
Heterotopic transplantation of normal A/J mouse… vs Heterotopic transplantation of normal A/J mouse…
Design
Preclinical
Follow-up
2 weeks after transplantation
Authors
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Cytokine elevation persists without virus; leaves open whether IL-1α/TNF-α inhibition merits human autoimmune myocarditis trials.
This preclinical study demonstrates that normal hearts transplanted into mice with chronic coxsackievirus B3-induced myocarditis develop myocarditis despite the absence of viral RNA, suggesting an autoimmune mechanism.
Nakamura et al. (1996) studied this question.
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