Chemical synthesis study demonstrates palladium-catalyzed tandem Heck carbonylation of indoles, suggesting broad utility for constructing complex chiral indolines.
-arylacyl indoles via a palladium-catalyzed tandem Heck/carbonylation, leading to an array of indoline-3-carboxylates bearing vicinal C2-aza-quaternary and C3 tertiary stereocenters in high yields and excellent enantio- and diastereoselectivities. This study is an important advance in the field of asymmetric carbonylation and enantioselective dearomatization reactions.
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Li et al. (2022) studied this question.
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