Population
Isolated perfused rat hearts (Langendorff preparations)
Comparison
Chronic pretreatment with isoproterenol (5 mg… vs Saline pretreatment
Design
Preclinical
Follow-up
10 days
Authors
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Indicates potential compensatory alpha1 upregulation after beta desensitization; leaves open relevance to human myocardial dysfunction.
Chronic beta-adrenoceptor stimulation induces beta-adrenoceptor desensitization while enhancing alpha1-adrenoceptor-mediated positive inotropic responsiveness, suggesting a compensatory mechanism for maintaining myocardial function.
Silva et al. (2001) studied this question.
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