Population
Isolated hearts
Design
Preclinical
Authors
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May link ATP depletion to arrhythmogenic beta-receptor sensitization in ischemia; hypothesis-generating in animal models, needs human validation.
The loss of high-energy phosphates during myocardial ischemia prevents normal beta-adrenergic receptor desensitization, leading to receptor sensitization that may trigger malignant arrhythmias.
Strasser et al. (1988) studied this question.
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