Key result
Hyperbaric oxygen preconditioning preserved cardiac structures in doxorubicin-treated rats despite increasing cardiac oxidative stress compared to doxorubicin alone.
Absolute Event Rate: 2.35% vs 1.87%
p-value: p=0.06
Animal findings leave open hyperbaric oxygen as a cardioprotectant in doxorubicin models; no basis for clinical use yet.
BACKGROUND: therapy in a DOX-induced cardiomyocyte injury animal model. METHODS: in doxorubicin induced cardiotoxicity. At the end of the protocols, the hearts were harvested and blood samples (2 ml) were obtained. RESULTS: The doxorubicin treated animals (Group 2) had increased oxidative stress markers (both cardiac and serum) and severe cardiac injury as compared to the basal findings in the control group. Nevertheless, the highest cardiac oxidative stress index was detected in Group 3 (control vs. Group 3, p = 0.01). However, histological examination revealed that cardiac structures were well preserved in Group 3 when compared with Group 2. CONCLUSIONS: .
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Tezcan et al. (2017) studied Doxorubicin-induced cardiotoxicity (n=21). Hyperbaric oxygen (HBO2) preconditioning vs. Doxorubicin alone was evaluated on Cardiac oxidative stress index (OSI) (p=0.06). Hyperbaric oxygen preconditioning preserved cardiac structures in doxorubicin-treated rats despite increasing cardiac oxidative stress compared to doxorubicin alone.
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