σ-Chelation-directed C–H functionalizations using Pd( ii ) and Cu( ii ) catalysts: regioselectivity, stereoselectivity and catalytic turnover

Recent progress in sigma-chelation directed C-H functionalization from the authors' group is described to illustrate the challenges and opportunities in the development of synthetically-useful catalytic reactions involving C-H activation as the key step. Emphasis is placed on strategies for developing catalysis under mild conditions and controlling regio- and stereoselectivity.