ATP-dependent adrenaline uptake in chromaffin granules may occur partly in response to a membrane potential generated by an electrogenic proton-translocating ATPase.
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Membrane potential may contribute to catecholamine storage; extends mechanistic models but leaves open human relevance pending translational studies.
Membrane vesicles ('ghosts') formed from bovine chromaffin granules accumulate adrenaline in response to a diffusion potential produced by adding K+ in the presence of valinomycin. This uptake occurs as a short (2--5 min) burst because of the transient nature of the diffusion potential. The potential-driven uptake is optimal at pH approximately 7.2, is inhibited by reserpine, and has an initial rate comparable with that of ATP-driven uptake. These results show that ATP-dependent adrenaline uptake may occur at least partly in response to the membrane potential generated by an electrogenic proton-translocating adenosine triphosphatase found in chromaffin-granule membranes.
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Njus et al. (1979) studied this question.
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