Why the study?
Does resting-state brain activity differ between patients with migraine without aura and healthy controls?
Population
18 patients with migraine without aura (MwoA) and 18 age- and gender-matched healthy controls (HC)
Design
Case-control
Key result
Migraine without aura was associated with decreased ALFF in the left rostral anterior cingulate cortex and bilateral prefrontal cortex, and increased ALFF in the right thalamus versus controls.
Authors
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Suggests potential neuroimaging markers but should not alter clinical practice; leaves open causal mechanisms and diagnostic utility.
Case-Control (n=36)
Does resting-state brain activity differ between patients with migraine without aura and healthy controls?
Patients with migraine without aura exhibit altered regional spontaneous neuronal activity and functional connectivity in specific brain regions during rest.
Xue et al. (2013) conducted a case-control in Migraine without aura (n=36). Migraine without aura vs. Healthy controls was evaluated on Amplitude of low-frequency fluctuation (ALFF) and functional connectivity. Migraine without aura was associated with decreased ALFF in the left rostral anterior cingulate cortex and bilateral prefrontal cortex, and increased ALFF in the right thalamus versus controls.