Key result
Patients with migraine without aura had significantly decreased regional homogeneity in the right rACC, PFC, OFC, and SMA compared to healthy controls.
Population
26 patients with migraine without aura and 26 age-, education- and gender-matched healthy volunteers (n=52)
Design
Case-control
Authors
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May indicate disrupted pain processing in migraine; hypothesis-generating for fMRI biomarkers, validation needed before clinical use.
Case-Control (n=52)
Patients with migraine without aura exhibit resting-state brain activity abnormalities in regions associated with pain processing.
Yu et al. (2011) conducted a case-control in Migraine without aura (n=52). Migraine without aura vs. Healthy volunteers was evaluated on Regional homogeneity (ReHo) values. Patients with migraine without aura had significantly decreased regional homogeneity in the right rACC, PFC, OFC, and SMA compared to healthy controls.
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