Key result
Dexmedetomidine administration in patients with preexisting cardiac conduction abnormalities or reliance on high sympathetic tone may provoke life-threatening cardiovascular events, including death.
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Dexmedetomidine should be avoided in patients with known sinus and A-V conduction problems or insufficient cardiovascular reserve due to the risk of life-threatening sympatholytic effects.
Talke et al. (2008) conducted an editorial in Preexisting cardiac conduction abnormalities. Dexmedetomidine was evaluated. Dexmedetomidine administration in patients with preexisting cardiac conduction abnormalities or reliance on high sympathetic tone may provoke life-threatening cardiovascular events, including death.
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