Key result
Administration of a dexmedetomidine infusion as an adjunct to general anesthesia in a patient with myasthenia gravis was associated with severe bradycardia progressing to asystole.
Population
1 52-year-old woman with myasthenia gravis undergoing thymectomy and excisional biopsy of a right lung mass…
Design
Case_report
Follow-up
4 days postoperatively
Authors
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May warrant caution with dexmedetomidine in myasthenia gravis anesthesia; leaves open generalizability and causality from this single case.
Case Report (n=1)
No
Dexmedetomidine infusion during general anesthesia may contribute to severe bradycardia and asystole, particularly in the presence of other negative chronotropic influences and surgical vagal stimulation.
Ingersoll-Weng et al. (2004) conducted a case report in Myasthenia gravis (n=1). Dexmedetomidine was evaluated on Cardiac arrest (asystole). Administration of a dexmedetomidine infusion as an adjunct to general anesthesia in a patient with myasthenia gravis was associated with severe bradycardia progressing to asystole.
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