November 24, 2004AnesthesiologyOpen Access

Dexmedetomidine and Asystole

Q: What is the clinical evidence from this study?

Study design: Letter. Population: Healthy patients undergoing laparoscopic gynecological procedures (n=40). Intervention: Dexmedetomidine. Primary outcome: Asystole.

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Key result

Among 40 healthy women receiving dexmedetomidine during laparoscopic gynecological procedures, there was one case (2.5%) of severe bradycardia and one case (2.5%) of asystole.

Population

40 healthy patients aged 20-40 years scheduled for laparoscopic gynecological procedures

Design

Case_series

Follow-up

intraoperative

Authors

RVRogério Luiz da Rocha VideiraLinde (United States)RFRoberto Manara Victório FerreiraFundação de Apoio à Universidade Federal de São Paulo

Discussion

Member takes

Implication

May signal rare bradyarrhythmic risk with dexmedetomidine in laparoscopy; hypothesis-generating and requires confirmation in larger cohorts.

Structured PICO

Population

40 healthy women aged 20-40 years undergoing laparoscopic gynecological procedures who received a dexmedetomidine infusion.

Intervention

Dexmedetomidine (initial infusion 4 μg·kg−1·h−1 for 15 min followed by 0.3 μg·kg−1·h−1) added to sevoflurane, fentanyl, and cisatracurium

Outcome

Incidence of severe bradycardia and asystolesafety

Dexmedetomidine use during laparoscopic gynecological procedures may be associated with severe bradycardia and asystole.

Cite This Study

Videira et al. (2004) conducted a letter in Healthy patients undergoing laparoscopic gynecological procedures (n=40). Dexmedetomidine was evaluated on Asystole. Among 40 healthy women receiving dexmedetomidine during laparoscopic gynecological procedures, there was one case (2.5%) of severe bradycardia and one case (2.5%) of asystole.

synapsesocial.com/papers/6a95105fbfa5337e2a0f2e4e https://doi.org/10.1097/00000542-200412000-00037

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November 24, 2004AnesthesiologyOpen Access

Dexmedetomidine and Asystole

View Full Paper

Ask AI

Bookmark

Key result

Among 40 healthy women receiving dexmedetomidine during laparoscopic gynecological procedures, there was one case (2.5%) of severe bradycardia and one case (2.5%) of asystole.

Population

40 healthy patients aged 20-40 years scheduled for laparoscopic gynecological procedures

Design

Case_series

Follow-up

intraoperative

Authors

RVRogério Luiz da Rocha VideiraLinde (United States)RFRoberto Manara Victório FerreiraFundação de Apoio à Universidade Federal de São Paulo

Discussion

Member takes

Implication

May signal rare bradyarrhythmic risk with dexmedetomidine in laparoscopy; hypothesis-generating and requires confirmation in larger cohorts.

Structured PICO

Population

40 healthy women aged 20-40 years undergoing laparoscopic gynecological procedures who received a dexmedetomidine infusion.

Intervention

Dexmedetomidine (initial infusion 4 μg·kg−1·h−1 for 15 min followed by 0.3 μg·kg−1·h−1) added to sevoflurane, fentanyl, and cisatracurium

Outcome

Incidence of severe bradycardia and asystolesafety

Dexmedetomidine use during laparoscopic gynecological procedures may be associated with severe bradycardia and asystole.

Cite This Study

synapsesocial.com/papers/6a95105fbfa5337e2a0f2e4e https://doi.org/10.1097/00000542-200412000-00037

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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