Key result
On-pump CABG was associated with a higher incidence of postoperative atrial fibrillation (35% vs 20%) and significantly elevated serum GGT levels compared to off-pump CABG.
Why the study?
Postoperative AF causes serious complications after open-heart surgery, and oxidative stress factors such as serum GGT may play a role in its unknown pathophysiology.
Does off-pump CABG reduce the incidence of postoperative atrial fibrillation and oxidative stress (measured by serum GGT) compared to on-pump CABG?
Cohort (n=183)
No
Does off-pump CABG reduce the incidence of postoperative atrial fibrillation and oxidative stress (measured by serum GGT) compared to on-pump CABG?
On-pump CABG is associated with a higher incidence of postoperative atrial fibrillation and elevated serum GGT levels (a marker of oxidative stress) compared to off-pump CABG.
Answers are grounded in this paper and cite their sources.
Should not yet change CABG technique selection; hypothesis-generating for off-pump benefit on POAF and oxidative stress.
Introduction: Atrial fibrillation (AF) which can be seen as a complication of the open-heart surgery, may cause serious problems on postoperative period. The exact pathophysiology of AF is unknown but it is thought that factors such as oxidative stress might cause AF. Material and methods: We retrospectively surveyed the serum gamma-glutamyl transferase (GGT) levels which is accepted as a mediator of oxidative stres, for the Post Operative Atrial Fibrillation (POAF) that occur after of-pump versus on-pump Coronary Artery Bypass Graft (CABG) surgery. Our study included 183 cases (101 male, 72 female; median age 63 ± 4.3 years) of which CABG was performed. Results: Echocardiography, routine blood tests, electrocardiography (ECG), test for the serum GGT levels were performed in preoperative and postoperative period to all participants. AF developed in 34 patients (35 %) in Group I and 19 patients (20 %) in Group II. There were no significant differences between two groups (of-pump versus on-pump) in terms of gender, cardiovascular risk factors and the severity of the coronary artery disease. In patients who has developed AF in postoperative period had significantly higher serum GGT levels. Conclusion: This study has shown that serum GGT levels were found to be significantly higher in patients whom AF has developed after on-pump CABG surgery.
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A 2020 study conducted a cohort in Coronary Artery Disease requiring CABG (n=183). On-pump CABG vs. Off-pump CABG was evaluated on Postoperative Atrial Fibrillation (POAF). On-pump CABG was associated with a higher incidence of postoperative atrial fibrillation (35% vs 20%) and significantly elevated serum GGT levels compared to off-pump CABG.
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