Key result
Off-pump coronary artery bypass grafting yielded a non-significantly lower incidence of early postoperative atrial fibrillation compared to on-pump CABG (15.8% vs 30.3%; P=0.071).
Why the study?
Atrial fibrillation is the most prevalent postoperative arrhythmic complication after CABG, but comparative data between on-pump and off-pump techniques are limited.
Does off-pump CABG reduce the incidence of early postoperative atrial fibrillation compared to on-pump CABG in patients undergoing surgical revascularization?
RCT (n=128)
simple
Does off-pump CABG reduce the incidence of early postoperative atrial fibrillation compared to on-pump CABG in patients undergoing surgical revascularization?
Absolute Event Rate: 15.8% vs 30.3%
p-value: p=0.071
Off-pump CABG was associated with a numerically lower incidence of early postoperative atrial fibrillation compared to on-pump CABG, although this difference did not reach statistical significance.
Background Among postoperative arrhythmic complications, atrial fibrillation (AF) exhibits the greatest prevalence after coronary artery bypass grafting (CABG). This study investigates the comparative prevalence of AF between on-pump and off-pump techniques. Aim To compare the POAF (post-operative atrial fibrillation) incidence between off-pump and on-pump CABG Methods A randomized (simple) cohort study prospectively investigated the influence of surgical practice in CABG, contrasting off-pump (OPCAB) and on-pump (ONCAB) methods, on the early postoperative occurrence of atrial fibrillation (POAF), defined as within the first 24 hours post-surgery. In a cohort of 128 consecutive patients (95 off-pump, 33 on-pump), the study compared groups based on preoperative factors (age, left ventricular ejection fraction < 40%, raised creatinine, hypertension, and graft location (right coronary (Rt), left circumflex arteries (LCX)) and the incidence of the POAF. Results ONCAB showed approximately twice the POAF incidence (30.3% versus 15.8% OPCAB, though not significantly (p=0.071). ONCAB had nearly double the POAF incidence (30.3% vs. 15.8%), though this difference was not statistically significant (p=0.071). Additionally, age and grafting of LCX/Rt. were significant predictors for POAF in the OPCAB group, while renal impairment was significant in both groups. Conclusion We conclude that Renal Impairment is a key predictor of postoperative adverse events (POAFS) across CABG techniques. However, age and LCX/Rt. Grafting significantly increases the risk of postoperative atrial fibrillation (POAF), particularly after OPCAB. ONCAB, while showing higher POAF incidence numerically, presents a distinct risk factor profile, emphasising the importance of a surgical approach in POAF risk assessment.
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Mohamed et al. (2026) conducted an RCT in Atrial fibrillation post coronary artery bypass grafting (n=128). Off-pump coronary artery bypass grafting (OPCAB) vs. On-pump coronary artery bypass grafting (ONCAB) was evaluated on Early postoperative occurrence of atrial fibrillation (POAF) within the first 24 hours post-surgery (p=0.071). Off-pump coronary artery bypass grafting yielded a non-significantly lower incidence of early postoperative atrial fibrillation compared to on-pump CABG (15.8% vs 30.3%; P=0.071).
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