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A case of hypergammaglobulinaemia, IgM and IgD deficiency, recurrent lymphadenppathy, and mononucleosis is described. Investigation revealed low titres of isohaemagglutinin and low levels of diphtheria antitoxin (neither of which responded to antigenic stimulation), slightly delayed rejection of skin homograft and anergy to tuberculin. The increased susceptibility to infection and the immunoglobulin abnormality were considered to be primary, and not secondary to acquired disease. Case reports of isolated IgM deficiency from the literature are briefly summarized, and some non-malignant causes of mononucleosis are mentioned.
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Schumacher et al. (1967) studied this question.
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