Key result
Lifestyle intervention in children and bariatric surgery in adults modulated a shared set of 15 lipid species after six months, suggesting a core circulating lipid profile signature in obesity.
Why the study?
To assess the circulating lipidome of children with obesity before and after lifestyle intervention and compare it to adults with obesity before and after bariatric surgery.
Do metabolic interventions (lifestyle recommendations or bariatric surgery) alter the circulating lipidome similarly in pediatric and adult patients with obesity?
Cohort (n=40)
No
Do metabolic interventions (lifestyle recommendations or bariatric surgery) alter the circulating lipidome similarly in pediatric and adult patients with obesity?
A shared set of lipid species is modulated after metabolic interventions in both children and adults with obesity, indicating a potential core lipid signature for obesity development and treatment response regardless of age.
Hypothesis-generating for pediatric lipidomic shifts after lifestyle intervention; leaves open adult bariatric comparisons.
The objective is to assess the circulating lipidome of children with obesity before and after lifestyle intervention and to compare the data to the circulating lipidome of adults with obesity before and after bariatric surgery. Ten pediatric (PE) and thirty adult (AD) patients with obesity were prospectively recruited at a referral single center. The PE cohort received lifestyle recommendations. The AD cohort underwent bariatric surgery. Clinical parameters and lipidome were analyzed in serum before and after six months of metabolic intervention. The abundance of phosphatidylinositols in the PE cohort and phosphatidylcholines in the AD significantly increased, while O-phosphatidylserines in the PE cohort and diacyl/triacylglycerols in the AD decreased. Fifteen lipid species were coincident in both groups after lifestyle intervention and bariatric surgery. Five species of phosphatidylinositols, sphingomyelins, and cholesteryl esters were upregulated. Eight species of diacylglycerols, glycerophosphoglycerols, glycerophosphoethanolamines, and phosphatidylcholines were downregulated. Most matching species were regulated in the same direction except for two phosphatidylinositols: PI(O-36:2) and PI(O-34:0). A specific set of lipid species regulated after bariatric surgery in adult individuals was also modulated in children undergoing lifestyle intervention, suggesting they may constitute a core circulating lipid profile signature indicative of early development of obesity and improvement after clinical interventions regardless of individual age.
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Soria‐Gondek et al. (2023) conducted a cohort in Obesity (n=40). Lifestyle intervention and bariatric surgery vs. Baseline was evaluated on Circulating lipidome changes. Lifestyle intervention in children and bariatric surgery in adults modulated a shared set of 15 lipid species after six months, suggesting a core circulating lipid profile signature in obesity.
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