Key result
Salvia miltiorrhiza injection significantly improved left ventricular systolic end pressure and left ventricular developed pressure in diabetic rats compared with no treatment.
Population
Adult male Sprague-Dawley rats with streptozotocin-induced diabetes (n=30)
Comparison
Salvia miltiorrhiza injection for 4 weeks vs No treatment and saline treatment
Design
Preclinical, randomized into three groups
Follow-up
4 weeks
Authors
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Hypothesis-generating for myocardial protection in diabetic cardiomyopathy; human trials required before any clinical consideration.
RCT (n=30)
randomized
Salvia miltiorrhiza injection demonstrates myocardial protection in a rat model of diabetic cardiomyopathy, potentially mediated by downregulation of TSP-1 and TGF-β1.
Yu et al. (2012) conducted an RCT in streptozotocin-induced diabetes (n=30). Salvia miltiorrhiza injection vs. no treatment (diabetes) and saline treatment (no diabetes) was evaluated on Left ventricular systolic end pressure and left ventricular developed pressure. Salvia miltiorrhiza injection significantly improved left ventricular systolic end pressure and left ventricular developed pressure in diabetic rats compared with no treatment.
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