Why the study?
Do new local anaesthetics (ropivacaine, levobupivacaine) and adjuvants (clonidine, ketamine) improve safety and efficacy in paediatric regional anaesthesia compared to older drugs?
Do new local anaesthetics (ropivacaine, levobupivacaine) and adjuvants (clonidine, ketamine) improve safety and efficacy in paediatric regional anaesthesia compared to older drugs?
This review highlights that newer local anesthetics like ropivacaine and levobupivacaine, along with adjuvants like clonidine and ketamine, provide safe and effective perioperative pain control in children.
May support preferring ropivacaine or levobupivacaine with adjuvants in paediatric blocks; leaves open need for dedicated RCTs.
Over the years paediatric regional anaesthesia has gained a worldwide consensus, and it can now be considered a significant part of perioperative pain control in children. As in many fields, with the use of drugs administered epidurally there is a fundamental need for safety and efficacy. Two new local anaesthetic agents have recently entered the market, ropivacaine and levobupivacaine, which seem to offer a wider safety margin in comparison with the old drugs as well as valid pain control. To prolong their analgesic duration, many adjuvants can be used, and clonidine and ketamine are probably the best solution. This review summarizes the most recent data on these drugs and their use in children.
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Ivani et al. (2001) studied this question.
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