Population
Human rhabdomyosarcoma (RD) cells and HeLa cells infected with group B coxsackieviruses (CB)
Comparison
Serial "blind" passages in human… vs Prototype CB3 virus
Design
Preclinical
Authors
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Should not change myocarditis management; leaves open whether dual receptor binding alters cardiac tropism in vivo.
Serial passage of coxsackievirus B3 in rhabdomyosarcoma cells leads to the acquisition of a second receptor attachment site, suggesting multiple receptor specificities may operate in host range mutant selection.
Reagan et al. (1984) studied this question.
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