Population
Eukaryotic RNA binding proteins containing multiple RNA binding domains or RNA Recognition Motifs
Design
Review
Authors
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Necessitates accounting for linkers in RBD affinity models; extends additive assumptions but leaves open in vivo specificity.
Linker sequences between RNA binding domains are critical determinants of binding affinity and may modulate cis versus trans binding in multi-RBD proteins.
Shamoo et al. (1995) studied this question.
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