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April 19, 2022Blood PressureOpen Access

Utility of ambulatory blood pressure monitoring in detection of masked hypertension and risk of hypertension mediated organ damage in normotensive patients with type 2 diabetes mellitus

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Key result

Masked hypertension was present in 66% of normotensive patients with diabetes and was significantly associated with concentric left ventricular hypertrophy (P=0.001) and nephropathy (P=0.008).

Why the study?

In patients with diabetes, unrecognized hypertension is a serious risk factor for the development and progression of chronic complications.

Does ambulatory blood pressure monitoring detect masked hypertension and predict hypertension-mediated organ damage in normotensive patients with type 2 diabetes mellitus?

Population

150 normotensive diabetic patients

Design

Cross-sectional observational study

Authors

HGHemant GuptaGrant Medical College and Sir Jamshedjee Jeejeebhoy Group of HospitalsTVTushar VidhaleGrant Medical College and Sir Jamshedjee Jeejeebhoy Group of HospitalsMPManas PustakeTexas Tech University

Discussion

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Implication

ABPM may identify masked hypertension warranting monitoring in normotensive T2DM; association with LVH and nephropathy remains hypothesis-generating.

Study Design

Type

Cross-Sectional (n=150)

Structured PICO

Does ambulatory blood pressure monitoring detect masked hypertension and predict hypertension-mediated organ damage in normotensive patients with type 2 diabetes mellitus?

P
Population
150 normotensive patients with diabetes underwent ambulatory blood pressure monitoring to assess the prevalence of masked hypertension and its association with diabetes complications.
E
Exposure
Ambulatory blood pressure monitoring (ABPM)
O
Outcome
Prevalence of masked hypertension and its association with diabetes complications (concentric LVH, nephropathy)surrogate

Main Result

p-value: p=0.001

ABPM reveals a high prevalence of masked hypertension (66%) in normotensive diabetic patients, which is significantly associated with target organ damage such as concentric LVH and nephropathy.

Cite This Study

Gupta et al. (2022) conducted a cross-sectional in Type 2 diabetes mellitus (n=150). Masked hypertension and abnormal dipping patterns was evaluated on Prevalence of masked hypertension and association with concentric LVH and nephropathy (p=0.001). Masked hypertension was present in 66% of normotensive patients with diabetes and was significantly associated with concentric left ventricular hypertrophy (P=0.001) and nephropathy (P=0.008).

synapsesocial.com/papers/6a85a1cfd1e5e0588dd4ec66https://doi.org/10.1080/08037051.2022.2061415

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ambulatory Blood Pressure Monitoring in Normotensive and Hypertensive Type 2 Diabetics Prevalence of Impaired Diurnal Blood Pressure Patterns1993 · 114 citations
  2. 2Masked Hypertension: A Review2007 · 228 citations
  3. 3Ambulatory blood pressure. An independent predictor of prognosis in essential hypertension.1994 · 1,682 citations
  4. 4Nondipping of Nocturnal Blood Pressure Is Related to Urinary Albumin Excretion Rate in Patients With Type 2 Diabetes Mellitus1996 · 78 citations
  5. 5Prognostic Effect of the Nocturnal Blood Pressure Fall in Hypertensive Patients2016 · 519 citations