Key result
Transgenic mice with increased adipose tissue lipoprotein lipase (Adipoq-LPL) showed improved glucose and insulin tolerance and increased energy expenditure when challenged with a high fat diet.
Why the study?
Does increasing adipocyte lipoprotein lipase improve glucose metabolism in high fat diet-induced obesity in mice?
Population
Transgenic mice (Adipoq-LPL) and control mice challenged with a high fat diet (HFD)
Comparison
Transgenic expression of lipoprotein lipase in… vs Control mice on a high fat diet
Design
Preclinical
Authors
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Caution against clinical translation of adipose LPL enhancement; leaves open its therapeutic potential in human obesity.
Does increasing adipocyte lipoprotein lipase improve glucose metabolism in high fat diet-induced obesity in mice?
Increasing adipose tissue lipoprotein lipase improves glucose metabolism and protects against obesity-induced insulin intolerance by enhancing adipose tissue function.
Walton et al. (2015) studied High fat diet-induced obesity. Transgenic expression of lipoprotein lipase (LPL) in adipocytes (Adipoq-LPL) vs. Control mice was evaluated on Glucose and insulin tolerance, energy expenditure, and adipose tissue phenotype. Transgenic mice with increased adipose tissue lipoprotein lipase (Adipoq-LPL) showed improved glucose and insulin tolerance and increased energy expenditure when challenged with a high fat diet.
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