Key result
Increased expression of lipoprotein lipase in transgenic rabbits does not lead to abnormalities in skeletal and heart muscles, refuting its suggested role in causing myopathies.
Population
LPL transgenic rabbits
Design
Preclinical
Authors
Loading...
Does not implicate LPL overexpression in myopathy; leaves open species differences and human relevance.
Increased LPL expression in transgenic rabbits does not cause myopathies, challenging previous findings in transgenic mice.
Koike et al. (2002) studied this question. Increased expression of lipoprotein lipase in transgenic rabbits does not lead to abnormalities in skeletal and heart muscles, refuting its suggested role in causing myopathies.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: