September 1, 2000AJP Regulatory Integrative and Comparative Physiology

Low LBNP tolerance in men is associated with attenuated activation of the renin-angiotensin system

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Why the study?

Is lower body negative pressure tolerance associated with the degree of renin-angiotensin system activation in healthy men?

Population

15 healthy men on a controlled diet, divided into high-tolerance and low-tolerance groups.

Comparison

Lower body negative pressure for 30 min from -15… vs Comparison between high-tolerance and…

Design

Other

Follow-up

30 minutes

Authors

JGJ. E. GreenleafQuinnipiac University TPTrine Welløw PetersenRigshospitalet AGAnders GabrielsenChr. Hansen (Denmark)

Discussion

Member takes

Implication

Attenuated RAS activation was associated with lower LBNP tolerance; hypothesis-generating for orthostatic tolerance and should not yet change practice.

Structured PICO

Is lower body negative pressure tolerance associated with the degree of renin-angiotensin system activation in healthy men?

Population

15 healthy men on a controlled diet (2,822 cal/day, 2 mmol/kg/day Na+), divided into high-tolerance (n=7, age 25 +/- 2 years) and low-tolerance (n=8, age 26 +/- 3 years) groups.

Intervention

Lower body negative pressure (LBNP) for 30 min from -15 to -50 mmHg

Comparator

Comparison between high-tolerance (HiTol) and low-tolerance (LoTol) groups

Outcome

Plasma vasoactive hormone concentrations (epinephrine, norepinephrine, ANG II, vasopressin, endothelin-1) and plasma renin activity (p(RA)) during LBNPsurrogate

Attenuated activation of the renin-angiotensin system is associated with lower tolerance to hypotensive stress (LBNP) and presyncope in healthy men.

Cite This Study

Greenleaf et al. (2000) studied this question.

synapsesocial.com/papers/6a85a85bf047f857d83dbbc7 https://doi.org/10.1152/ajpregu.2000.279.3.r822

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September 1, 2000AJP Regulatory Integrative and Comparative Physiology

Low LBNP tolerance in men is associated with attenuated activation of the renin-angiotensin system

View Full Paper

Ask AI

Bookmark

Why the study?

Is lower body negative pressure tolerance associated with the degree of renin-angiotensin system activation in healthy men?

Population

15 healthy men on a controlled diet, divided into high-tolerance and low-tolerance groups.

Comparison

Lower body negative pressure for 30 min from -15… vs Comparison between high-tolerance and…

Design

Other

Follow-up

30 minutes

Authors

JGJ. E. GreenleafQuinnipiac University TPTrine Welløw PetersenRigshospitalet AGAnders GabrielsenChr. Hansen (Denmark)

Discussion

Member takes

Implication

Attenuated RAS activation was associated with lower LBNP tolerance; hypothesis-generating for orthostatic tolerance and should not yet change practice.

Structured PICO

Is lower body negative pressure tolerance associated with the degree of renin-angiotensin system activation in healthy men?

Population

15 healthy men on a controlled diet (2,822 cal/day, 2 mmol/kg/day Na+), divided into high-tolerance (n=7, age 25 +/- 2 years) and low-tolerance (n=8, age 26 +/- 3 years) groups.

Intervention

Lower body negative pressure (LBNP) for 30 min from -15 to -50 mmHg

Comparator

Comparison between high-tolerance (HiTol) and low-tolerance (LoTol) groups

Outcome

Plasma vasoactive hormone concentrations (epinephrine, norepinephrine, ANG II, vasopressin, endothelin-1) and plasma renin activity (p(RA)) during LBNPsurrogate

Attenuated activation of the renin-angiotensin system is associated with lower tolerance to hypotensive stress (LBNP) and presyncope in healthy men.

Cite This Study

Greenleaf et al. (2000) studied this question.

synapsesocial.com/papers/6a85a85bf047f857d83dbbc7 https://doi.org/10.1152/ajpregu.2000.279.3.r822

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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