Why the study?
Does Zaprinast alter vascular tone and vasodilator responses in the cat pulmonary vascular bed?
Population
Cat pulmonary vascular bed under conditions of controlled blood flow and constant left atrial pressure
Comparison
Zaprinast injections into the perfused lobar… vs Baseline conditions, elevated tone conditions…
Design
Preclinical
Authors
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Hypothesis-generating for PDE5 inhibition in pulmonary vasodilation; leaves open translation to human pulmonary hypertension therapy.
Does Zaprinast alter vascular tone and vasodilator responses in the cat pulmonary vascular bed?
Zaprinast decreases lobar arterial pressure and prolongs vasodilator responses, suggesting rapid cGMP hydrolysis in the lung and the importance of endothelium-derived NO in regulating basal vascular tone.
McMahon et al. (1993) studied this question.
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