Why the study?
Does nicardipine, theophylline, or zaprinast restore cardiovascular haemodynamics following inhibition of nitric oxide synthesis with L-NAME in anaesthetized pigs?
Does nicardipine, theophylline, or zaprinast restore cardiovascular haemodynamics following inhibition of nitric oxide synthesis with L-NAME in anaesthetized pigs?
In a pig model, nicardipine completely reversed the increased afterload and reduced cardiac output caused by NO synthesis inhibition, suggesting a potential strategy for managing adverse haemodynamic effects of NO synthase inhibitors in septic shock.
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May support calcium channel blockade for NO inhibition effects in shock models; leaves open translation to human septic shock.
Herity et al. (1994) studied this question.
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