Why the study?
Does cyclooxygenase or thromboxane synthesis blockade alter pulmonary hemodynamics during exercise in sheep?
Population
11 yearling sheep (healthy lung model)
Comparison
Cyclooxygenase or thromboxane synthesis blockade… vs Paired studies without drug treatment
Design
Preclinical
Authors
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Does not support COX or thromboxane blockade to alter exercise pulmonary hemodynamics in sheep; leaves open relevance to human disease.
Does cyclooxygenase or thromboxane synthesis blockade alter pulmonary hemodynamics during exercise in sheep?
Thromboxane A2 and prostacyclin do not modulate pulmonary hemodynamics during maximal or prolonged exercise in the normal sheep lung.
Newman et al. (1986) studied this question.
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