August 5, 2005The Journal of PhysiologyOpen Access

Nitric oxide blunts the endothelin‐mediated pulmonary vasoconstriction in exercising swine

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Population

15 instrumented swine

Comparison

ET/ET receptor blockade (tezosentan, 3 mg kg… vs Baseline conditions

Design

Preclinical

Authors

BHBirgit HouwelingErasmus MC DMDaphne MerkusVascular Medicine MDMarjolein M. D. DekkerErasmus MC

Discussion

Member takes

Implication

Endothelin-NO interplay during exercise warrants targeted human studies; leaves open translation to clinical pulmonary vascular disease management.

Structured PICO

Population

15 instrumented swine

Intervention

ET(A)/ET(B) receptor blockade (tezosentan, 3 mg kg(-1) I.V.) in the presence and absence of inhibition of NO synthase (N(omega)-nitro-L-arginine, 20 mg kg(-1) I.V.) and/or cyclo-oxygenase (indometacin, 10 mg kg(-1) I.V.) during treadmill exercise

Comparator

Baseline conditions (absence of receptor blockade/inhibition)

Outcome

Pulmonary and systemic vascular resistancesurrogate

In a swine model, nitric oxide, but not prostanoids, blunts endothelin-mediated pulmonary vasoconstriction during exercise.

Cite This Study

Houweling et al. (2005) studied this question.

synapsesocial.com/papers/6a7aa86d02ab7a73dd0306af https://doi.org/10.1113/jphysiol.2005.094227

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Implication

Endothelin-NO interplay during exercise warrants targeted human studies; leaves open translation to clinical pulmonary vascular disease management.

Nitric oxide blunts the endothelin‐mediated pulmonary vasoconstriction in exercising swine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Nitric oxide blunts the endothelin‐mediated pulmonary vasoconstriction in exercising swine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider