Key result
During acute shear stress across the collecting duct, ENaC acts in a negative feedback loop to stimulate NO production in an ETB/NOS1-dependent manner, decreasing ENaC open probability.
During acute shear stress across the collecting duct, ENaC acts in a negative feedback loop to stimulate NO production in an ETB/NOS1-dependent manner, resulting in a decrease in ENaC open probability and promoting natriuresis.
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No immediate clinical implications for sodium handling; leaves open translation of this mechanosensitive pathway to human hypertension.
Hyndman et al. (2014) studied this question. Acute shear stress and ET-1 treatment vs. Basal conditions / Flox control mice was evaluated on ENaC open probability and NO production. During acute shear stress across the collecting duct, ENaC acts in a negative feedback loop to stimulate NO production in an ETB/NOS1-dependent manner, decreasing ENaC open probability.
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