June 9, 2016AJP Regulatory Integrative and Comparative PhysiologyOpen Access

High salt induces autocrine actions of ET-1 on inner medullary collecting duct NO production via upregulated ETBreceptor expression

View Full Paper

Ask AI

Bookmark

Population

Vascular endothelial ET-1 knockout mice (VEETKO), collecting duct ET-1 KO (CDET-1KO), and flox controls

Comparison

High-salt diet for 7 days, with or without ETB… vs Flox controls; baseline (before high-salt diet)

Design

Preclinical

Follow-up

7 days

Authors

KHKelly A. HyndmanUniversity of Alabama at Birmingham CDCourtney DugasTulane University AAAlexandra M. ArguelloMayo Clinic in Arizona

Discussion

Member takes

Implication

Emphasizes collecting duct ET-1 specificity for IMCD NO on high salt; leaves open human translation and therapeutic targeting.

Structured PICO

Population

Vascular endothelial ET-1 knockout mice (VEETKO), collecting duct ET-1 KO (CDET-1KO), and flox controls

Intervention

High-salt diet for 7 days (HS7), with or without ETB receptor blockade or NOS1 inhibition

Comparator

Flox controls; baseline (before high-salt diet)

Outcome

Nitrite production (a metabolite of NO) by inner medullary collecting ducts (IMCD)surrogate

During high-salt feeding, autocrine actions of collecting duct-derived ET-1 via ETB receptor upregulation are critical for IMCD NO production and inhibition of ion reabsorption.

Cite This Study

Hyndman et al. (2016) studied this question.

synapsesocial.com/papers/6a815c1bd7cc36764366294a https://doi.org/10.1152/ajpregu.00016.2015

View Full Paper

Ask AI

Bookmark

High salt induces autocrine actions of ET-1 on inner medullary collecting duct NO production via upregulated ETBreceptor expression

Discussion

Member takes

Implication

Structured PICO

Cite This Study

High salt induces autocrine actions of ET-1 on inner medullary collecting duct NO production via upregulated ETBreceptor expression

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider