Why the study?
Does tumor necrosis factor-alpha decrease endothelium-derived nitrovasodilators in pulmonary artery endothelial cells?
Population
Calf pulmonary artery endothelial monolayers (PAEM)
Comparison
Tumor necrosis factor-alpha for 15 min or 18 h vs Control treatment
Design
Preclinical
Follow-up
18 hours
Authors
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TNF may impair pulmonary endothelial NO via PKC and oxidative stress; leaves open relevance to human pulmonary vascular disease.
Does tumor necrosis factor-alpha decrease endothelium-derived nitrovasodilators in pulmonary artery endothelial cells?
Tumor necrosis factor-alpha decreases pulmonary artery endothelial nitric oxide production via a protein kinase C-dependent pathway and oxidative stress.
Johnson et al. (1994) studied this question.
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