Key result
Chloride transmembrane transport and its regulating protein complexes play a significant role in influencing the bioelectrical activity and electrophysiological properties of cardiomyocytes.
Why the study?
Multiple chloride-conducting transmembrane proteins and regulatory mechanisms have been identified in the heart, underlying complex effects on the pacemaker, conduction system, and working myocardium.
Design
Review
Authors
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Chloride conductances shape myocardial electrophysiology; leaves open their therapeutic targeting in arrhythmias.
This review provides a comprehensive overview of the molecular mechanisms and structural basis of chloride transmembrane transport and its role in the electrophysiological properties of cardiomyocytes.
Voronina et al. (2024) reported a review. Chloride transmembrane transport and its regulating protein complexes play a significant role in influencing the bioelectrical activity and electrophysiological properties of cardiomyocytes.
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