Key result
Arterionephrosclerosis may result from complex environmental and genetic factors rather than a direct linear relationship to hypertension-induced damage.
This perspective highlights that arterionephrosclerosis may result from complex environmental and genetic factors rather than a direct linear relationship with hypertension.
May prompt reevaluation of hypertension-centric models in nephrosclerosis; leaves open multifactorial genetic-environmental research.
The morphological findings of so-called hypertensive nephrosclerosis, rather than implying a linear direct relationship to damage induced by hypertension, may indicate complex environmental and genetic factors, which together foster the coexistence of renal lesion and hypertension in this clinical setting. We discuss the clinical and pathological criteria for diagnosis of arterionephrosclerosis, and possible pathogenetic factors, including hypertension, ethnicity, aberrant autoregulation, prothrombotic mechanisms, low birth weight, decreased nephron number, genetic factors and dysmetabolic syndrome.
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Marcantoni et al. (2007) conducted a review in Arterionephrosclerosis (hypertensive nephrosclerosis). Pathogenetic factors (hypertension, genetics, environment) was evaluated. Arterionephrosclerosis may result from complex environmental and genetic factors rather than a direct linear relationship to hypertension-induced damage.
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