November 1, 1995Circulation Research

Description of a Nonselective Cation Current in Human Atrium

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Population

Isolated human atrial myocytes from 17 different hearts (n=142 cells), including adult and pediatric hearts.

Design

Preclinical

Authors

WCWilliam CrumbNova Research Company (United States)JPJohn D. PigottUniversity of Oklahoma CCC W ClarksonTulane University

Discussion

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Implication

Hypothesis-generating for a role in atrial repolarization; leaves open arrhythmogenic relevance pending functional validation.

Structured PICO

Population

Isolated human atrial myocytes from 17 different hearts (n=142 cells), including adult and pediatric hearts.

Intervention

Whole-cell patch-clamp technique with ion substitutions (e.g., replacing pipette K+ with Cs+, altering bath Cl- and Na+ concentrations) and exposure to 4-aminopyridine, isoproterenol, or cell swelling.

Outcome

Electrophysiological characterization of a rapidly activating outward current (amplitude, reversal potential, ion selectivity, and modulation).surrogate

This study provides the first description of a nonselective cation current in human atrial myocytes, which may contribute to atrial repolarization.

Cite This Study

Crumb et al. (1995) studied this question.

synapsesocial.com/papers/6a85ad2ef03ba6f1e32026ea https://doi.org/10.1161/01.res.77.5.950

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Description of a Nonselective Cation Current in Human Atrium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Description of a Nonselective Cation Current in Human Atrium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider