Key result
A meta-analysis of 2.5 million single nucleotide polymorphisms in 5,823 African Americans failed to identify any loci associated with coronary artery calcification at genome-wide significant levels.
Meta-Analysis (n=5,823)
Yes
This large GWAS meta-analysis in African Americans found substantial heritability for coronary artery calcification (~30%) but did not identify any genome-wide significant loci, highlighting the need for larger, ethnically targeted cohorts.
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No actionable loci for CAC risk prediction in African Americans yet; leaves open the need for larger ancestry-specific GWAS.
Wojczynski et al. (2013) conducted a meta-analysis in Coronary artery calcification (n=5,823). Genetic variants (SNPs) vs. Reference alleles was evaluated on Log transformed coronary artery calcification quantity (ln(CAC + 1)). A meta-analysis of 2.5 million single nucleotide polymorphisms in 5,823 African Americans failed to identify any loci associated with coronary artery calcification at genome-wide significant levels.
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