Key result
In African American adults, the coronary artery calcium score was independently associated with prevalent cardiovascular disease (OR 1.22; 95% CI 1.12-1.32; p<0.0001).
Why the study?
Does the addition of coronary artery calcium (CAC) score to the Framingham Risk Score improve diagnostic accuracy for prevalent cardiovascular disease in African Americans?
Cross-Sectional (n=2,944)
Does the addition of coronary artery calcium (CAC) score to the Framingham Risk Score improve diagnostic accuracy for prevalent cardiovascular disease in African Americans?
Odds Ratio: 1.22 (95% CI 1.12–1.32)
p-value: p=< 0.0001
In African Americans, adding the coronary artery calcium score to the Framingham Risk Score significantly improves diagnostic accuracy and risk reclassification for prevalent cardiovascular disease.
CAC addition was associated with better CVD discrimination in AAs; leaves open whether it improves outcomes or warrants routine screening.
BACKGROUND: The role of coronary artery calcium (CAC) as a screening tool for cardiovascular disease (CVD) risk in African Americans (AAs) is unclear. We compared the diagnostic accuracy for CVD prevalence using the CAC score and the Framingham Risk Score (FRS) in an adult population of AAs. METHODS: CAC was measured in 2944 participants AAs. Approximately 8% of this cohort had known CVD defined as prior myocardial infarction, stroke, percutaneous coronary intervention, coronary artery bypass grafting and peripheral artery disease. Logistic regression, receiver operating characteristic (ROC) and net reclassification index (NRI) analysis were used adjusting for age, gender, systolic blood pressure (SBP), total and high-density lipoprotein (HDL) cholesterol, smoking status, diabetes mellitus (DM), body mass index (BMI), blood pressure medication and statin use. Participants with prevalent clinical CVD and DM were classified as high FRS risk. RESULTS: The mean age of participants was 60 years, 65% were females, 26% had DM, 50% were obese and 30% were current or former smokers. Prevalent CVD was associated with older age, higher SBP, lower HDL and total cholesterol, and higher CAC. The prevalence of CAC was 83% in participants with prevalent CVD and 45% in those without CVD. CAC was independently associated with prevalent CVD in our multivariable model [OR (95% CI): 1.22 (1.12-1.32), p< 0.0001]. In ROC analysis, CAC improved the diagnostic accuracy (c statistic) of the FRS from 0.617 to 0.757 (p < 0.0001) for prevalent CVD. Addition of CAC to FRS resulted in net reclassification improvement of 4% for subjects with known CVD and 28.5% in those without CVD. CONCLUSION: In AAs, CAC is independently associated with prevalent CVD and improves the diagnostic accuracy of FRS for prevalent CVD by 14%. Addition of CAC improves the NRI of those with prevalent CVD by 4% and the NRI of individuals without CVD by 28.5%. Determination of CAC may be useful in CVD risk stratification in AAs.
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Sung et al. (2015) conducted a cross-sectional in Cardiovascular disease (n=2,944). Coronary artery calcium (CAC) score vs. Framingham Risk Score (FRS) was evaluated on Prevalent cardiovascular disease (OR 1.22, 95% CI 1.12-1.32, p=< 0.0001). In African American adults, the coronary artery calcium score was independently associated with prevalent cardiovascular disease (OR 1.22; 95% CI 1.12-1.32; p<0.0001).
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