September 1, 1984Diabetes Care

Autonomic Neural Dysfunction in Recently Diagnosed Diabetic Subjects

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Why the study?

Is autonomic nervous system function impaired soon after the diagnosis of diabetes mellitus compared to controls?

Population

19 non-insulin-dependent diabetic subjects with known duration ≤12 months, 14 insulin-dependent diabetic…

Comparison

Measurement of autonomic nervous system… vs Control subjects

Design

Cross-sectional

Authors

CWClarice R. WeinbergUniversity of North Carolina at Chapel Hill DCDaniel L. CookSeattle Pacific University ARAndrew ReenanUniversity of Washington Medical Center

Discussion

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Implication

Early autonomic impairment may occur soon after diabetes diagnosis; hypothesis-generating for screening and longitudinal outcome studies.

Structured PICO

Is autonomic nervous system function impaired soon after the diagnosis of diabetes mellitus compared to controls?

Population

19 non-insulin-dependent (NIDD) diabetic subjects with known duration ≤12 months, 14 insulin-dependent (IDD) diabetic subjects with known duration ≤24 months, and control subjects (including 6 normal subjects for a volume depletion test).

Intervention

Measurement of autonomic nervous system (ANS) function, including RR-variation during beta adrenergic blockade, dark-adapted pupil size after topical PNS blockade, and pupillary latency time.

Comparator

Control subjects

Outcome

Autonomic nervous system function indices (RR-variation, dark-adapted pupil size, and pupillary latency time)surrogate

Autonomic nervous system impairment, including cardiac parasympathetic dysfunction, is detectable very early after the diagnosis of both insulin-dependent and non-insulin-dependent diabetes mellitus.

Cite This Study

Weinberg et al. (1984) studied this question.

synapsesocial.com/papers/6a85b124734852141cd4dbeb https://doi.org/10.2337/diacare.7.5.447

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Autonomic Neural Dysfunction in Recently Diagnosed Diabetic Subjects

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Autonomic Neural Dysfunction in Recently Diagnosed Diabetic Subjects

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider