What question did this study set out to answer?

To review the structure, biology, and host-defense functions of mammalian cathelicidins, with a focus on human hCAP18/LL-37.

January 1, 2005Open Access

The Role of Cathelicidins in the Innate Host Defenses of Mammals

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Review demonstrates multifunctional defense roles of cathelicidins in mammals, highlighting the importance of LL-37 in human innate immunity.

To review the structure, biology, and host-defense functions of mammalian cathelicidins, with a focus on human hCAP18/LL-37.
Synthesized evidence on the storage, two-domain structure, and activation cleavage of cathelicidins in mammalian neutrophils and epithelia.
Evaluated functional roles and biological activities of the cathelin segment and the C-terminal LL-37 peptide in human innate host defense.
Cathelicidins are produced as dual-domain precursors that are cleaved upon demand into an active cathelin protein and an antimicrobial peptide, both contributing to host protection.
Human LL-37 acts as a multifunctional mediator that coordinates diverse immune responses beyond direct antimicrobial killing, functioning as an essential component of human innate defense.

Margherita Zanetti (2005) studied this question.

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January 1, 2005Open Access

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Authors

Review demonstrates multifunctional defense roles of cathelicidins in mammals, highlighting the importance of LL-37 in human innate immunity.

To review the structure, biology, and host-defense functions of mammalian cathelicidins, with a focus on human hCAP18/LL-37.
Synthesized evidence on the storage, two-domain structure, and activation cleavage of cathelicidins in mammalian neutrophils and epithelia.
Evaluated functional roles and biological activities of the cathelin segment and the C-terminal LL-37 peptide in human innate host defense.
Cathelicidins are produced as dual-domain precursors that are cleaved upon demand into an active cathelin protein and an antimicrobial peptide, both contributing to host protection.
Human LL-37 acts as a multifunctional mediator that coordinates diverse immune responses beyond direct antimicrobial killing, functioning as an essential component of human innate defense.

Margherita Zanetti (2005) studied this question.

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