Enantiomer separation by capillary SFC and GC on immobilized octakis(2,6‐di‐O‐methyl‐3‐O‐pentyl)‐γ‐cyclodextrin

Heptakis(2,6‐di‐ O ‐methyl‐3‐ O ‐pentyl) (2‐ O ‐methyl‐6‐ O ‐oct‐1‐enyl‐3‐O‐pentyl)‐γ‐cyclodextrin was immobilized to narrow‐bore fused silica capillaries after selective modification. One tert ‐butyldimethylsilyl group was introduced into octakis‐(2‐ O ‐methyl‐3‐ O ‐pentyl)‐γ‐cyclodextrin in order to get a pure monofunctionalized cyclodextrin derivative. During synthesis the tert ‐butyldimethylsilyl group was replaced by an anchoring group to bind the cyclodextrin to a polysiloxane. After thermal immobilization of the modified polysiloxane this new chiral stationary phase was applied in GC and SFC. High efficiency separations were obtained in GC. In SFC very polar compounds could be chromatographed at low temperatures resulting in higher separation factors as compared to GC.