Permethyl‐β‐cyclodextrin, Chemically Bonded to Polysiloxane: a Chiral Stationary Phase with Wider Application Range for Enantiomer Separation by Capillary Gas Chromatography

Underivatized alkanediols and alkylcarboxylic acids, hydroxy(di)carboxylic acid methyl esters and cyanohydrins, as well as alkanes and derivatized amino acids : enantiomeric mixtures of all of these compound classes have been shown to be separable by gas chromatography on the new stationary phase permethylpolysiloxane permethylcyclodextrin 1. A column containing this material can be programmed for use up to 280 °C even though the substance is neither cross-linked nor chemically bonded to the glass surface. Separations described here were performed at temperatures between 100 and 200 °C.