Cyclodextrins as chiral stationary phases in capillary gas chromatography. Part II: Heptakis(3‐O‐acetyl‐2,6‐di‐O‐pentyl)‐ß‐cyclodextrin

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Heptakis (3‐ O ‐acetyl‐2,6‐di‐ O ‐pentyl)‐ß‐cyclodextrin is used as a chiral stationary phase in capillary gas chromatography. High enantioselectivity towards trifluoro‐acetylated α and β‐chiral amines, amino alcohols, α‐ and β‐amino acid esters, and cyclic trans‐diols is observed. In contrast to chiral polysiloxane phases, where hydrogen bonding interaction is essential for enantiomer separation, in cyclodextrins inclusion properties contribute to enantioselectivity. This can be concluded from the separation of N ‐alkylated amino compounds. The new chiral stationary phase exhibits a wide operating temperature range and is stable above 200°C.